Fig. 6: Defactinib reduces inflammation in Hh/anti-IL10R-model of murine colitis.
From: Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
a H&E staining of large intestine tissue sections. Scalebar depicts 100 µM. b histology scoring and c leucocyte content from Hh/anti-IL10R-treated mice, which received either vehicle or defactinib. Data in (b, c) shown as mean values ± SEM from n = 6 mice per condition. Statistical significance was calculated by a two-tailed unpaired t-test where P = 0.0025 for colon histopathology and P = 0.02 for leucocyte content. d Cytokine/chemokine mRNA expression levels in mouse colon tissue, leucocyte-enriched colonic cells, monocytes/macrophages from a vehicle or defactinib Hh/anti-IL10R treated mice. Data were shown as mean values ± SEM from n = 6-8 mice per condition for tissues and leucocytes. Samples were pooled to give n = 3 for monocytes/macrophages. Statistical significance was calculated by a two-tailed unpaired t-test (*P < 0.05 and **P < 0.01). Source data are provided as a Source Data file.
