Fig. 6: Seasonal and annual fluctuation in HCoV reactivity. | Nature Communications

Fig. 6: Seasonal and annual fluctuation in HCoV reactivity.

From: Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity

Fig. 6: Seasonal and annual fluctuation in HCoV reactivity.

Reactivity to human coronaviruses (HCoV-NL63, HCoV-229E, HCoV-HKU1, HCoV-OC43) was compared by ABCORA 5.0. Reactivity in healthy blood donors from 2019 and 2020 was compared. Pre-pandemic samples included: January 2019 (N = 285), May 2019 (N = 288), January 2020 (N = 252). Samples from May 2020 (N = 672) were collected during the pandemic in Switzerland. Only samples without SARS-CoV-2 specific reactivity as defined by ABCORA were included (N = 653). Stars correspond to levels of significance of two-sided t-tests comparing the indicated groups. Levels of significance are corrected by the Bonferroni method for multiple testing and indicated as follows: *p < 0.05/36, **p < 0.01/36, ***p < 0.001/36. Boxplots represent the following: median with the middle line, upper and lower quartiles with the box limits, 1.5x interquartile ranges with the whiskers and outliers with points.

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