Fig. 10: Macrophages and neutrophils in human IBC.
a Hierarchical clustering of human IBCs and non-IBCs based on expression of genes characteristic for tumor-associated macrophages (TAMs) in breast cancer. TAM-specific 37-gene signature30 was applied to microarray data from human IBCs (n = 41) and non-IBCs (n = 55)24. Percentile rank of gcrma normalized microarray signal intensities was z-score transformed and z-scores are shown. b Human IBC samples immunostained with antibodies against CD68 for macrophages and CD66b for neutrophils, as indicated. Images shown are representative of n = 9 tumors with different clinical presentations of IBC: IBC presenting as a solid tumor (tumor 1), as a lymphovascular emboli (tumor 2) or with highly diffuse pattern of growth (tumor 3). Scale bars: 100 μm.
