Fig. 2: Protein–protein interactions predicted for proteins affected by pathogenic de novo mutations. | Nature Communications

Fig. 2: Protein–protein interactions predicted for proteins affected by pathogenic de novo mutations.

From: A de novo paradigm for male infertility

Fig. 2

Significantly larger number of interactions were observed in proteins affected by de novo mutations than expected for a similar sized dataset of randomly selected proteins (PPI enrichment p value = 2.35 × 10−2). The central module of the main interaction network (blue dashed circle) contains 5 proteins involved in mRNA splicing (Supplementary Fig. 6).

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