Fig. 3: Oxygen entry site and channel composition. | Nature Communications

Fig. 3: Oxygen entry site and channel composition.

From: Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase

Fig. 3

a Surface representation of CcO and its oxygen entry point located between the transmembrane helix (TMH) 1 and 3 in the hydrophobic transmembrane site. The illustrated map density is filtered to a contour level of 2. b Detailed composition of the oxygen-conducting channel based on their hydrophobicity. The illustrated map density is filtered to a contour level of 0.5. c Interior channel embedded in between six transmembrane helices and channel lining residues predicted by Mole 2.5. d Overlay of channel prediction and individually displayed lining residues with corresponding dioxygen densities. Dioxygen molecules are shown as purple sticks, the corresponding densities are highlighted by mesh volumes.

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