Fig. 2: CpGs in the EWAS of serum urate from the combined meta-analysis of discovery and replication results (n = 17,996). | Nature Communications

Fig. 2: CpGs in the EWAS of serum urate from the combined meta-analysis of discovery and replication results (n = 17,996).

From: Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Fig. 2: CpGs in the EWAS of serum urate from the combined meta-analysis of discovery and replication results (n = 17,996).

The CpGs are ordered by their chromosomal position on the x-axis with their –log10(p value) of the association on the y-axis. CpGs with positive and negative effect estimates are plotted in the upper and lower panels, respectively. The dotted horizontal lines represent the level of significance corrected for multiple testing (two-sided p < 1.1E–7). Black: replicated CpGs; brown: gene with replicated CpGs associated with gene expression in monocytes and significant causal effects for serum urate; blue: replicated CpGs with significant causal effects on serum urate or gout; red: replicated CpGs associated with gene expression in monocytes or whole blood. Gene names are displayed if the gene had at least one CpG with p value < 1E–14. MR Mendelian randomization.

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