Fig. 2: Axonal TDP-43 accumulation leads to formation of pathological RNP condensates. | Nature Communications

Fig. 2: Axonal TDP-43 accumulation leads to formation of pathological RNP condensates.

From: Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins

Fig. 2

a–c Images (a), colocalization profiles (b) and quantification (c) of TDP-43-G3BP1-SytoRNA colocalization in control or ∆NLS axons. Scale bar=10 µm. n = 28,35 axons. Data are presented as mean values ± SD. Unpaired-t-test, two-sided. ****p < 0.0001. d–f Images (d), colocalization profiles (e) and quantification (f) of pTDP-43-G3BP1-SytoRNA colocalization in control or C9ORF72 iPS-MN. Scale bar=10 µm. n = 108,104 axons. Data are presented as mean values ± SD. Unpaired-t-test, two-sided, ****p < 0.0001. g–i Images (g), colocalization profiles (h) and quantification (i) of pTDP-43-G3BP1 colocalization in non-ALS or ALS patient intra-muscular nerves. Scale bar=10 µm. n = 5,3 patients. Data are presented as mean values ± SEM. Unpaired-t-test, two-sided. *P = 0.0163. a.u stands for arbitrary units. Source data are provided as a Source Data file.

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