Fig. 9: Conditional MEGF10 or MERTK knockout in microglia/macrophages or astrocytes differentially affected behavioral outcomes in mice after ischemic and hemorrhagic stroke.

mNSS (a, b) and rotarod test (c–d) were performed to examine the neurobehavioral outcomes of ischemic mice. *, MEGF10^WT VS C-MEGF10^KO, MERTK^WT VS C-MERTK^KO; #, MEGF10^WT VS A-MEGF10^KO, MERTK^WT VS A-MERTK^KO. N = 17, 12, 13 mice (a); 19, 12, 11 mice (b); 11, 12, 10 mice (c); and 19, 13, 11 mice (d) (day 14, from left to right). e Representative images showed travel patterns in the smart cage. f, g Quantification of the time that mice of different groups stayed in the dark zone. N = 22, 17, 17 (f) and 22, 16, 15 mice (g) (from left to right). mNSS (h–i), rotarod test (j–k), and grid-walking test (l–m) were used to examine neurobehavioral outcomes of hemorrhagic mice at different time points. h–k *, MEGF10^WT VS C-MEGF10^KO, MERTK^WT VS C-MERTK^KO; &, MEGF10^WT VS A-MEGF10^KO, MERTK^WT VS A-MERTK^KO. N = 21, 12, 10 mice (h); 11, 11, 13 mice (i); 12, 14, 11 mice (j); and 11, 14, 11 mice (k) (day 14, from left to right). N = 11, 14, 13, 11, 13, 12 mice (l) and 11, 10, 11, 10, 10, 11 mice (m) (from left to right). a–d, h–m Two-way ANOVA followed by Tukey’s test; f, g one-way ANOVA followed by Tukey’s test. Data are mean ± SD.