Fig. 5: Discovery of an extended allosteric communication path through the Pol II–Rad26 complex from dynamic network analysis.
From: Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair
Dynamic communities directly traversed by the allosteric path (black dotted arrow) are shown in color. dCNA subgraphs for these communities of the Pol II–Rad26 complex are shown as insets, indicating gain(+)/loss(−) of dynamic contacts for the following transitions: (a) apo to ATP; (b) ATP to ADP; (c) ADP to apo. Non-participating communities are shown in gray. Red and green spheres denote residues with highest gain/loss of contact probability mapped onto the Pol II–Rad26 structures.
