Fig. 2: Identification of tumor cells and major epithelial cell types, including club cells. | Nature Communications

Fig. 2: Identification of tumor cells and major epithelial cell types, including club cells.

From: Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states

Fig. 2

a UMAP projection of all 20 clusters identified in the epithelial cells. Clusters are labeled in the UMAP. b Violin plots of representative marker genes across the clusters. c UMAP of epithelial cells annotated by cell types. d Heatmap of the top ten differentially expressed genes in each cell type (BE: basal epithelial cells; Other: other epithelial cells; Non-malignant LE: non-malignant luminal epithelial cells; ERG + Tumor: ERG + tumor cells; ERG− Tumor: ERG− tumor cells). e Club cell signature scores of each epithelial cell projected on the UMAP and signature score violin plots across all clusters. f Box plots of club cell signature scores from normal club cells and lung club cells across epithelial cell types (N = 13,322 cells, ***P < 0.001, Wilcoxon rank-sum test; normal club cell signature: P < 2.2e-16; normal club cell signature: P < 2.2e-16). Center, bounds, and percentiles are shown in the box plot. Source data are provided as a Source Data file.

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