Fig. 1: Example of a clinico-genomic analysis based on outcomes ascertained using natural language processing models: Association between TMB and progression-free survival after initation of immunotherapy.
From: Artificial intelligence-aided clinical annotation of a large multi-cancer genomic dataset
High tumor mutational burden defined as >=20 mutations per megabase. Results in this figure represent unadjusted Kaplan-Meier curves. Events were recorded using the “PFS-I-and-M” endpoint, defined as the earlier of death, or the time by which both a medical oncologist note and an imaging report had described cancer progression/worsening. Progression/worsening was defined using natural language processing models applied to imaging reports and medical oncologist notes. Survival curves were not adjusted for left truncation, since progression events were possible prior to genomic testing and cohort eligibility.
