Fig. 6: The ‘arginine loop’ plays a central role in RNA recognition.
From: Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch
a–c Details of rRNA recognition by 2A. For each copy of 2A, selected residues involved in interactions are labelled and shown as sticks. <Insets> View of the rRNA surface bound by each copy of 2A. The rRNA helices are colour-coded and labelled. The 2A contact surface is shown as a coloured mesh (orange, red and yellow, respectively). d–f, Close-up view of interactions between the 2A ‘arginine loop’ residues (R95, R97 and R100) and the rRNA backbone (sticks) for each copy of 2A (orange, red, yellow). Polar or electrostatic contacts are indicated by a green dashed line.
