Table 1 Mammary cell states corresponding to scRNA-seq clusters.

From: Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1

Cluster

Lineage

Stem cell genes

Proliferation

Differentiation potential

Cell state

0

Basal (KRT14+)

Upregulated

Lum + Basal

Bipotent stem

1

Basal (KRT14+)

Upregulated

+

Basal

Basal progenitor

2,3,5,7

Basal (KRT14+)

Downregulated

Basal

Mature basal

4

Luminal (KRT8+)

Downregulated

Luminal

Mature luminal

6

Luminal (KRT8+)

Upregulated

+

Luminal

Luminal progenitor

  1. Summary of cluster identification using: lineage information derived from cytokeratin expression; stem cell gene expression enrichment determined by GSEA; proliferative potential based on Ki67 expression and cell cycle gene enrichment; and differentiation potential determined by the presence of cells within a cluster along lineage reconstruction paths by Monocle. Alongside the summaries of cluster characteristics are the identities of the mammary cell states to which these clusters were assigned.