Fig. 7: Effect of α2-antiplasmin deficiency on amyloid deposition. | Nature Communications

Fig. 7: Effect of α2-antiplasmin deficiency on amyloid deposition.

From: Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis

Fig. 7

Amyloid deposition was enhanced by α2-antiplasmin deficiency (P = 0.0068, Mann–Whitney test, two-tailed). Estimates of lingual amyloid content (individual values, mean and SD) are shown for male line N4 human TTRS52P mice that were wild-type (control) or homozygous for an α2-antiplasmin knockout allele (n = 10 each group). The tissues were collected 2 months after amyloid deposition was seeded by injection of human TTRS52P amyloidotic spleen homogenate. Similar results were obtained when comparing α2-antiplasmin deficient (homozygous knockout) with control heterozygous α2-antiplasmin knockout male mice (P = 0.0047, Mann–Whitney test, two-tailed, n = 7 controls, 6 knockouts). Source data are provided as a Source Data file.

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