Fig. 2: High fat diet mice physiologic parameters and enrichment of m6Am-modified genes in GO terms associated with metabolic processes.
From: Dynamic regulation of N6,2′-O-dimethyladenosine (m6Am) in obesity
a Gain in weight of mice fed a high fat diet (HFD) or regular chow diet across weeks. N = 10 (5 HDF mice, and 5 Chow lean control mice), error bars denote SEM. b NMR measurement of lean and fat mass body composition, indicating that the gain in weight was mainly in fat mass. N = 10 (5 HDF mice, and 5 Chow lean control mice). c Fold change of read end counts (IP/Input) within a sliding window of 5 base-pairs around a reported adenosine TSS in the Fabp2 gene in lean (chow) and HFD mice. All adenosines in the sequence are indicated. d Sequence logo of the m6Am peaks around and upstream the annotated TSS within the DNA, portraying the canonical m6Am genomic consensus. e. Gene ontology analysis of m6Am and CDS m6A (>50 nt of TSS) showing a clear enrichment of m6Am- but not in m6A-modified genes, in GO terms associated with metabolic processes. Source data are provided as a Source Data file.
