Fig. 1: Characterization of genome-wide significant cis-mCpGs and cis-mQTLs.
From: Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome
a Enrichment of the identified cis-mCpGs in comparison to all tested CpGs in relation to UCSC CpG islands and gene functional regions (annotations from R IlluminaHumanMethylationEPICanno.ilm10b2.hg19 package) and chromatin states modeled for CD4+ T cells (annotations from Roadmap Epigenomics Project, sample #E043). Significant enrichment/depletion are shown using upwards/downwards arrows, respectively. b Percentage of our identified cis-mCpGs available in the BLUEPRINT study and the comparison between the two studies regarding the direction of effect and significance of association for the lead mSNPs are shown on the left. Comparison between the effect sizes found in our study and in BLUEPRINT are shown on the right.
