Fig. 5: DNA methylation effects of MS total polygenic score.
From: Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome
a Manhattan plot shows association p-values between CpG methylation levels and MS total polygenic score. Red horizontal line shows the significance threshold (FDR < 5%). Top CpGs in the three significant regions are specified. The genomic location for cg16050799 (the top associated CpG outside the MHC region, red vertical line) in relation to nearby CpGs, genes, and modeled chromatin states, in addition to its association with the MS total polygenic score (Z-scores) is further shown. Error band represents 95% confidence interval. Methylation levels are shown in M values. b Genomic locations of MS susceptibility alleles nominally associated with cg16050799 methylation (p < 0.05) are shown. Gene sets enriched for genes associated with these loci are specified.
