Table 1 Demographic characteristics of main and replication study participants.
From: Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome
Study | Sample size | Tissue | Methylation kit | Diagnosis | Age (mean ± SD) | Sex (F/M) | EDSS range | MS medication |
|---|---|---|---|---|---|---|---|---|
Main study | 156 | CD4 + T cell | Illumina EPIC | MS | 41.6 ± 6.9 | 106/50 | 0–4 | all treated (79 GA, 77 DMF) |
Replication - BLUEPRINT | 132 | naïve CD4 + T cell | Illumina 450 K | HC | 55.3 ± 11.0 | 75/57 | – | – |
Replication - UC Berkeley | 208 | whole blood | Illumina 450 K | MS | 48.2 ± 9.8 | 208/0 | 0–5.5 | 13 never treated, 195 treateda |
Replication - PhenoGenetic | 48 | CD4 + T cell | targeted | HC | 34.6 ± 11.0 | 25/23 | – | – |
Replication - GOLDN | 717 (related individuals) | CD4 + T cell | Illumina 450 K | HC | 48.5 ± 15.9 | 361/356 | – | – |
