Fig. 1: Stimulation of T-cell-mediated cancer immunotherapy. | Nature Communications

Fig. 1: Stimulation of T-cell-mediated cancer immunotherapy.

From: Biomimetic nanoparticles deliver mRNAs encoding costimulatory receptors and enhance T cell mediated cancer immunotherapy

Fig. 1

a Illustration of enhanced cancer immunotherapy via nanoparticles delivering costimulatory receptor mRNA followed by the injection of agonistic antibodies to costimulatory receptors (e.g., PL1-OX40 mRNA + anti-OX40 antibody). b Representative synthetic routes to biomimetic compounds: phospholipid and glycolipid derivatives. i. Et3N, Toluene, RT. ii. Et3N, DMF, RT. iii. TFA, CH2Cl2, RT. iv. aldehyde, Et3N, THF, NaBH(OAc)3. c Structures of phospholipid derivatives PL1-PL18 and glycolipid derivatives GL1-GL16.

Back to article page