Fig. 3: IFNγ and IL-10 responses and associated cell types. | Nature Communications

Fig. 3: IFNγ and IL-10 responses and associated cell types.

From: Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction

Fig. 3: IFNγ and IL-10 responses and associated cell types.

Spearman correlations between IFNγ signaling and its canonical response protein (CXCL9), as well as proteins associated with activated T cells (IL2RA), NK cells (NCR1), and macrophages (CD163) for patients with (MIS-C; N = 22), Minimal Severe Acute Respiratory Syndrome Corona Virus 2 infection (SARS-CoV-2; N = 26) infection, and Severe Corona Virus Disease (COVID-19; N = 15) compared to healthy controls (N = 25) are shown in panel a. Correlations between IL-10 and its canonical receptor IL12B, as well as IL2RA, NCR1, and CD163 for each disease category are shown in panel b. Panel c shows correlations between HLADR+CD38+ CD8+ T cells (N = 19) and IFNγ, CXCL9, and IL-10. Dots are colored by each patient’s disease category. Panel d demonstrates correlations between HLADR+CD38+ CD4+ T cells (N = 19) and IFNγ, CXCL9, and IL-10. Dots are colored by disease category. Error bars represent 95% confidence interval. All p-values were calculated with a two-sided test. Source data are provided as a Source Data file.

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