Fig. 6: Clinical heterogeneity among MIS-C patients defined by their IFNγ signature.

a Overlaps between patients who meet criteria for macrophage activation syndrome (MAS), thrombotic microangiopathy (TMA), and MIS-C. b Differentially expressed proteins between patients with IFNγ-low (N = 13) and IFNγ-high expression (N = 7). Log2fold change threshold of 2 and a nominal p-value cutoff of 0.05 were used. c Unsupervised pathway ranking and d network analysis for differentially expressed proteins between IFNγ-low and IFNγ-high patients. e Maximum ferritin level during admission for patients in the IFNγ-low (N = 12) and IFNγ-high (N = 7) groups. P-value computed using Wilcoxon test. Horizontal line represents median, with bounds of box representing interquartile range. Whiskers represent 1.5x the interquartile range. Dots represent outliers. f Number of patients in IFNγ-low (N = 13) and IFNγ-high (N = 7) groups who did and did not require inotropic support. P-value computed with Fisher’s exact test. NTproBNP expression between IFNγ-low (N = 13) and IFNγ-high groups (N = 7) (g) and in MIS-C patients who did (N = 7) and did not require inotropes (h; N = 15). Horizontal line represents median, with bounds of box representing interquartile range. Whiskers represent 1.5x the interquartile range. Dots represent outliers. i Correlation between IFNγ level and percent DR⁺CD38⁺ non-naïve CD8⁺ CX3CR1⁺ T cells in MIS-C patients (N = 7). Dots colored by CX3CL1 expression. R value computed using Pearson’s correlation coefficient after normality was demonstrated. Error band represents 95% confidence interval. j CX3CL1 levels between IFNγ-low (N = 13) and IFNγ-high groups (N = 7). P-values computed with Wilcoxon test. Horizontal line represents median, with bounds of box representing interquartile range. Whiskers represent 1.5x the interquartile range. Dots represent outliers. All p-values were calculated using two-sided tests. Source data are provided as a Source Data file.