Fig. 7: Aldehydic C–H diversification and scale-up synthesis in flow.
From: Divergent functionalization of aldehydes photocatalyzed by neutral eosin Y with sulfone reagents
a Aldehydic C–H azidation and vinylation. Reaction conditions unless otherwise noted: 1 (0.4 mmol), sulfone (0.2 mmol), eosin Y (4 mol%), and solvent (2.0 mL) in an argon-filled Schlenk tube (20 mL) under 470 nm light (18 W LED) irradiation. [a] Reaction was performed in CH3CN at room temperature. [b] Reaction was performed in ethyl acetate at 80 °C. b Reaction scale-up in continuous-flow microtubing reactors. Psi pound per square inch.
