Fig. 3: Density plot for sex comparison of PGSSCZ contributions to schizophrenia risk.
From: Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia
PGSSCZ predictions in case-control subsamples after bootstrap resampling (5000 permutations) of 500 schizophrenia patients (SCZ) and 500 healthy controls (HC) (selected from the overall CIBERSAM case-control sample) were performed in males (NSCZ = 1253; NHC = 859) and females (NSCZ = 674; NHC = 702), separately. Mean SCZ-HC variance explained by PGSSCZ on the liability scale (estimated prevalence of 0.01) in males and females was compared for predisposing variation within genome partitions. Variance explained in females and males was statistically compared with two-sided t-tests and is marked with an asterisk when it is significantly different (p < 0.05). A PGSSCZ predictions comparison from variants within SCZ[noLNL]. B PGSSCZ predictions comparison from variants within SCZ[LNL]. C PGSSCZ predictions comparison from variants within SCZ[CONC]. D PGSSCZ predictions comparison from variants within SCZ[DISC].
