Fig. 4: Annotation-stratified genetic covariance between schizophrenia and related traits.
From: Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia
We calculated covariances with GNOVA within SNP subsets from SCZ[noLNL], SCZ[CONC], and SCZ[DISC] annotations. P-values were calculated for the genetic covariance based on two-sided Wald tests. Error bars represent 95% confidence intervals based on standard errors (covariance estimation + /− 1.96*SE). FDR-corrected significant associations (pFDR < 0.05) are marked with an asterisk. Traits and disorders are abbreviated as follows: major depression (MDD), attention and deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), anxiety disorder (ANX), bipolar disorder (BIP), obsessive-compulsive disorder (OCD), alcohol dependence disorder (ALC-DEP), cross-disorder phenotype (CROSS-DIS), neuroticism (NEUR), depressive symptoms (DS), subjective well-being (SWB), psychotic experiences in the general population (PSY-EXP), educational attainment (EA), and body mass index (BMI). For further details of the phenotypes see Supplementary Data 6 and Supplementary Methods 6.
