Fig. 1: Single-cell transcriptomic landscape of esophageal squamous cell carcinoma (ESCC).

A A schematic graph showing the study design. B UMAP (Uniform Manifold Approximation and Projection) visualization of the clustering of 41,237 cells from all 22 nonmalignant and tumor samples, color coded by either major cell type (left), sample type (middle) or patient origin (right). C Overlay of expression of representative marker genes for each cell type defined in (B). D The frequency of each cell type in nonmalignant and tumor samples (left), and in each of the 11 patients (right, an analysis restricted within tumor samples). Source data are provided as a Source Data file.