Fig. 2: Detailed characterization of CD8+ T cells and intratumoral CD8+ cell differences in tumors with low and high inflammation scores. | Nature Communications

Fig. 2: Detailed characterization of CD8+ T cells and intratumoral CD8+ cell differences in tumors with low and high inflammation scores.

From: Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing

Fig. 2

A Sub-clustering of 27,013 CD8+ T cells (n = 18 patients; cluster 0–13) and visualization of relevant characteristics: patient contribution (HN01–HN18), viral-status (HPV+ vs. HPV–), inflammation score (low, medium, high; cells from the PBL, as well as all cells from HN03 were excluded) and CD8+ T cell sub-states (cycling, cytotoxic, naive-like, pre-dysfunctional, terminally exhausted). B Hallmark gene sets enriched (using the Computer Overlaps tool from MSigDB) in the top 100 DEGs between CD8+ T cells from high vs. low inflammation patients (and vice versa, all p < 0.01). p-values for enrichment were extrapolated from hypergeometric distribution.

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