Table 2 Clinical characteristics of the patients (all male) with aortic stenosis.

From: Skeletal muscle derived Musclin protects the heart during pathological overload

 

Aortic stenosis N = 26

Normal values

Healthy N = 56

Age (years)

79.4 ± 7.7****

 

60.5 ± 4.3

BMI (g/m2)

25.9 ± 3.1

18.5–25

 

Diabetes mellitus (n)

8

 

0

Echocardiography

 Ejection fraction (%)

45.7 ± 15.9 (n = 17)

>55

 

 Septum thickness (mm)

14.5 ± 0.5 (n = 25)

≤11

 

 Left ventricular enddiastolic diameter (mm)

48.9 ± 6 (n = 25)

42–58

 

 Aortic valve gradient, mean (mmHg)

37.4 ± 16.1

≤20

 

 Aortic valve area (cm2)

0.7 ± 0.18

>1.5

 

Serum

 Musclin (ng/ml)

2.36 ± 1*

 

3.38 ± 2.3

 Creatinine (µmol/l)

124.5 ± 58

59–104

 

Clinical classification [% of all patients]

  NYHA I

15.4

  

  NYHA II

23.1

  

  NYHA III

46.2

  

  NYHA IV

15.4

  

Medication [% of all patients]

  ACE inhibitor

50

  

  Angiotensin receptor antagonist

19.2

  

  β-receptor antagonist

69.2

  

  Diuretic

69.2

  

  Calcium channel antagonist

38.5

  
  1. The mean age and Musclin levels of the healthy individuals (also all male) are shown in addition to normal values.
  2. Data are displayed as mean ± SD or in % of all patients as indicated. BMI denotes body mass index. NYHA indicates New York Heart Association Class. *p = 0.0403 vs. Healthy (determined by two-tailed Mann–Whitney test) and ****p < 0.0001 (determined by two-tailed Student’s t test).
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