Fig. 4: NK cells decrease barcode diversity in NL-HABC infected mice.
From: Latency reversal plus natural killer cells diminish HIV reservoir in vivo
a Stacked bar plots display the relative frequencies and distribution of major barcode variants identified in the plasma, spleen, and bone marrow “BM” of mice treated with or without NK cells during ART interruption described in Fig. 2. Individual barcodes are represented by one color. “NR“ is no rebound, undetectable HIV RNA copies measured by qRT-PCR. “NA” is no amplicon detected of the barcode region by nested PCR. b Number of unique barcodes quantified by deep sequencing of viral RNA from pooled organs per mouse in the No NK (blue) and NK (red) groups. n = 12 biologically independent animals in the No NK group, n = 14 biologically independent animals in NK group. c Number of unique barcodes from the plasma (n = 11 biologically independent animals in no NK group, 13 biologically independent animals in NK group), spleen, and BM (n = 12 biologically independent animals in no NK group, n = 14 biologically independent animals in NK group) of each mouse. Horizontal bars represent the means. P values were calculated using the two-tailed Mann-Whitney test. Source data are provided as a Source Data file.
