Table 3 The anti-fungal, anti-bacterial activity, and hemolytic toxicity of TP-DB-designed AMP (W3_db5) and other AMPs containing the “W2W2W” motif.

From: Helical structure motifs made searchable for functional peptide design

Name

Sequence

MIC90 vs. C. albicans (μg/ml)

MIC90 vs. E. coli (μg/ml)

MHC5 (μg/ml)

W3_p1

KK WRK WLK WLA KK

7.5

15

120

W3_p2

KK WLK WLK WLK KK

7.5

15

90

W3_db5

KK WKC WAR WRL KK

3.75

30

>>240

W3_n1

KK WGN WGG WRL KK

N/A

>>120

N/A

W3_n2

KK WKD WES WRL KK

N/A

>>120

N/A

  1. MIC90 means the minimal concentration of AMP to inhibit 90% growth of pathogens, while MHC5 means the minimal concentration of AMP to induce 5% hemolysis against human erythrocytes. The three equally spaced tryptophans (W3, W6, and W9) are marked in bold and underlined.
Back to article page