Fig. 1: A high-fat diet induces alterations of adipose tissue and trabecular bone.
From: Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis
a Comparison of the body weight between NFD- and HFD-fed mice (n = 5 biologically independent samples). b Quantification of the mass of eWAT (n = 5 biologically independent samples) and iWAT (n = 5 biologically independent samples) of the NFD- and HFD-fed groups. c Representative μCT images (left) and quantification (right, n = 4 biologically independent samples) of rBMAT in the proximal tibiae of the NFD- and HFD-fed groups at the indicated time points. Scale bar: 500 μm. d Representative μCT images (left) and quantification of bone mass in proximal tibiae (right, n = 5 biologically independent samples). Scale bar: 500 μm. e Linear regression analysis of the BV/TV and body weight in HFD-fed mice (n = 17 biologically independent samples). f ITTs were performed at weeks 6, 8, and 12 in the NFD- and HFD-fed groups (n = 5 biologically independent samples). Images are representative of 3 independent experiments. All data are presented as mean ± SD. Two-way ANOVA with Sidak’s post-hoc test (a–d and f) were used. Source data are provided as a Source Data file.
