Fig. 4: Serum neutralizing antibody (NAb) and IgG antibody titers in different ages of ferrets.
From: Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
The NAb titers against SARS-CoV-2 NMC-nCoV02 (100 TCID50) among different age groups was measured in Vero cells with serially diluted ferret sera collected at 0, 12, and 21 dpi (a). The IgG titers among different age groups in serially diluted sera collected at 0, 12, and 21 dpi (b). Groups with the same letter are of the same subgroup in the post-hoc analysis. Lower case letters indicate significant differences at each time point (P values are a vs b: 0.00017 or 0.00168 (a), a vs b: 0.03 or 0.0044 (b)), while upper case letters indicate significant differences of area under the curve as change over the entire period (P values are A vs B: 0.0012 or 0.0233 (a), A vs B: 0.03 (b)). The area under the curve was calculated using Kruskal–Wallis with Bonferroni as a post-hoc analysis. Data were analyzed in GraphPad Prism 9.1.2. Data are presented as mean ± SEM (n = 3). The limit of detection for NAb titers and OD450 nm value is 0.5, indicated by the dotted line. Source data are provided as a Source Data file.
