Table 1 Clinical scores of ferrets infected with SARS-CoV-2.

From: Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets

Group

 

0 dpi

2 dpi

4 dpi

6 dpi

8 dpi

10 dpi

G1 (Juvenile)

Cough

0.00

0.00

0.00

0.00

0.00

0.00

Runny nose

0.00

0.56 ± 0.50

0.33 ± 0.47

0.00

0.00

0.00

Movement, activity

0.00

0.44 ± 0.50

0.17 ± 0.37

0.00

0.00

0.00

Total

0.00

1.00

0.50

0.00

0.00

0.00

G2 (Young adult)

Cough

0.00

0.33 ± 0.47

1.00

1.00

0.00

0.00

Runny nose

0.00

0.22 ± 0.42

1.33 ± 0.47*

1.00

0.00

0.00

Movement, activity

0.00

0.67 ± 0.67

1.83 ± 0.37**

1.67 ± 0.47***

1.00

0.00

Total

0.00

1.22

4.17

4.00

1.00

0.00

G3 (Aged adult)

Cough

0.00

0.56 ± 0.50

1.00

1.00

0.00

0.00

Runny nose

0.00

0.44 ± 0.68

1.67 ± 0.47††

1.33 ± 0.47†††

0.67 ± 0.47

0.33 ± 0.47

Movement, activity

0.00

0.78 ± 0.92

2.00**

2.00

1.00

0.67 ± 0.47

Total

0.00

1.78

4.67

4.00

1.67

1.00

  1. Observational clinical symptoms: Cough, rhinorrhea, movement, and activity. Score: 0; normal, 1: occasional, mild reduced activity, 2: frequent, reduced activity. Scores were measured by observation of clinical symptoms for at least 20 min in each group of ferrets based on the following criteria: Cough: 0; no evidence of cough, 1; occasional cough, 2; frequent cough (score 2). Rhinorrhea: 0; no nasal rattling or sneezing, 1; moderate nasal discharge on external nares, 2; severe nasal discharge on external nares. Movement, activity: 0; normal movement and activity, 1; mild reduced movement and activity, 2; evidence of reduced movement and activity.
  2. Asterisks and daggers indicate statistical significance compared with G1 (Juvenile) as evaluated by two tailed t-tests and nonparametric tests (*p = 0.0073, **p < 0.0001, ***p = 0.0075, p = 0.006, ††p = 0.0012 and †††p = 0.0161).