Fig. 4: Single-cell transcriptomics of the placental tissues from women with SARS-CoV-2 infection.
From: Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2
a Uniform Manifold Approximation and Projection (UMAP) plot showing the combined cell type classifications of the chorioamniotic membranes (CAM) and placental villi and basal plate (PVBP) from SARS-CoV-2 (+) (n = 9) or control women (n = 10), where each dot represents a single cell. Abbreviations used are CTB cytotrophoblast, EVT extravillous trophoblast, LED lymphoid endothelial decidual cell, npiCTB non-proliferative interstitial cytotrophoblast, STB syncytiotrophoblast. b UMAP plots showing cell populations separated based on placental compartment (CAM and PVBP) from SARS-CoV-2 (+) or control women. c Bar plots showing the numbers of each cell type in the CAM and PVBP of SARS-CoV-2 (+) or control women. d Numbers of differentially expressed genes (DEGs) associated with SARS-CoV-2 infection from the CAM and PVBP with false discovery rate (FDR) adjusted p < 0.1. e Quantile–quantile (Q–Q) plots showing the differential expression of all tested genes in each cell type of maternal or fetal origin from the CAM and PVBP samples. Deviation above the 1:1 line (solid black line) indicates enrichment.
