Fig. 4: The PPC regulates associative memory retrieval. | Nature Communications

Fig. 4: The PPC regulates associative memory retrieval.

From: A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating

Fig. 4

a Schematics showing labeling of the PPC neurons in c-fos-tTA transgenic mice with the LVs TRE3G-ArchT-EYFP or TRE3G-EYFP (left). Schematic of the behavioral experiment with optical silencing (right). Blue and gray bars indicate the presence or absence of Dox, respectively. Optical silencing to the PPC was delivered during test 1. b The graph shows the freezing level during the conditioning, reactivation, test 1, and test 2 (ArchT-Light OFF, n = 14 mice, ArchT-Light ON, n = 13 mice, EYFP-Light ON, n = 10 mice) (two-way ANOVA with RM followed by Sidak’s post hoc test, session: P < 0.0001, group: P = 0.6419, session × group: P = 0.0002). Error bars represent the mean ± s.e.m. *P < 0.05. Ctx context, IS an immediate shock. For details of statistical data, see Supplementary Table 1. Source data are provided as a Source Data file.

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