Fig. 5: Interaction dynamics in consensus TADs during folliculogenesis in chicken GCs.
From: Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis
a D-scores of consensus TADs located in the A and B compartments at each stage. b Expression levels of genes in consensus TADs (n = 1831) with a relatively low, medium, or high D-score. c Expression changes in genes with significantly increased, decreased, or stable D-scores between adjacent stages. d A representative TAD with differential D-scores during folliculogenesis. Top: Hi-C contact heatmaps of the genomic region containing CDH2 (Chr.2: 104.58–106.10 Mb). D-score values of the TADs were marked. Middle: TAD boundaries and genome browser tracks of PC1 values, ATAC-seq signals, and gene expression levels. Bottom: gene structures in the genomic region. The dashed line boxes indicate the chromosomal locations of the genes (red). For a, b, and c, the internal line indicates the median, the box limits indicate the upper and lower quartiles and the whiskers extend to 1.5 IQR from the quartiles. P-values in a were calculated using one-sided Student’s t test. P values in b and c were calculated using two-sided Wilcoxon rank-sum test. Source data are provided as a Source Data file.
