Fig. 3: Comparison of the selected CpG among the EPIC IDOL-Ext, 450k IDOL-Ext (legacy), and pickComProbes. | Nature Communications

Fig. 3: Comparison of the selected CpG among the EPIC IDOL-Ext, 450k IDOL-Ext (legacy), and pickComProbes.

From: Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

Fig. 3

a DNA methylation of the 1200 CpG probe EPIC IDOL-Ext library with average methylation for cell-type samples shown in columns as labeled and tracking bars for CpG probes information in the rows, including: present on 450k array (HM450k), tracking to transcription factor binding site (TFBS), DNA hypersensitivity site (DHS), enhancer region from Phantom5 annotation, and genomic context relative to gene (Function) and CpG island (CGI). b DNA methylation of the 1500 CpG probe 450k IDOL-Ext (legacy) library and c DNA methylation of the 1200 CpG pickComProbes library. The average DNA methylation levels (here as beta values) are represented per each of the 12 cell types. Information about CpG island gene context, Phantom5-enhancer information, DNase Hypersensitivity sites (DHS), Open chromatin, and annotated transcription factor binding sites (TFBS) from ENCODE included in the Illumina annotation file are summarized using the row ribbons. Source data are provided as a Source Data file. Bas Basophils, Eos eosinophils, Neu neutrophils, Bnv B-cells naïve, Bmem B-cells memory, CD4nv helper CD4(+) T-cells naïve, CD4mem helper CD4(+) T-cells memory, Treg CD4(+) T regulatory cells, CD8nv cytotoxic CD8(+) T-cells naïve, CD8mem cytotoxic CD8(+) T-cells memory, Mono monocytes, NK natural killer cells.

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