Table 1 Characteristics of the context of the different blood cell-type deconvolution libraries.
EPIC IDOL-Ext | 450k IDOL-Ext | EPIC IDOL-6 | pickCompProbes | |
|---|---|---|---|---|
n = 1200 | n = 1500 | n = 450 | n = 1200 | |
N (%) | N (%) | N (%) | N (%) | |
Genomic context | ||||
CpG Island | 50 (4) | 122 (8) | 10 (2) | 62 (5) |
Shores | 189 (16) | 388 (26) | 63 (14) | 146 (12) |
Shelves | 95 (8) | 213 (14) | 35 (8) | 90 (8) |
Open Sea | 866 (72) | 777 (52) | 342 (76) | 902 (75) |
Functional context | ||||
Promoter | 276 (23) | 558 (37) | 104 (23) | 271 (23) |
Exon | 88 (7) | 144 (10) | 25 (6) | 100 (8) |
Intron | 551 (46) | 556 (37) | 201 (45) | 548 (46) |
Intergenic | 285 (24) | 242 (16) | 120 (27) | 281 (23) |
Enhancers | 139 (12) | 76 (5) | 70 (16) | 194 (16) |
DHS | 856 (71) | 1001 (67) | 328 (73) | 868 (72) |
Open chromatin | 135 (11) | 174 (12) | 43 (10) | 113 (9) |
TFBS | 166 (14) | 193 (13) | 59 (13) | 147 (12) |
Contained in 450 K | 459 (38) | 1500 (100) | 149 (33) | 517 (43) |
Total overlap vs. Ref | ||||
vs. EPIC IDOL-Ext | Ref | 330 (22) | 43 (10) | 147 (12) |
vs. 450k IDOL-Ext | 330 (28) | Ref | 27 (6) | 89 (7) |
vs. EPIC IDOL-6 | 43 (4) | 27 (2) | Ref | 57 (5) |
vs pickCompProbes | 147 (12) | 89 (6) | 57 (13) | Ref |
