Fig. 3: NRPs/PKS act synergistically to eliminate sensitive Bacilli.

Clustered heatmap showing the calculated interaction scores between NRPs/PKS antibiotics. Interaction score =0 represents no interaction, >0 represents antagonistic interaction and <0 represents synergistic interactions. Each interaction score is the average of scores calculated from three independent experiments. Asterisks next to an antibiotic combination (competitor’s name) indicate that the interaction scores across the corresponding column (row) significantly deviated from 0 (p value < 0.05). P values were calculated for each combination of antibiotics and competitor using a two-tailed one-sample t-test, and the p values for all competitor (antibiotics combinations) were combined using Fisher’s methods (shown in Supplementary Data 1). Rows and columns of the heatmap were hierarchically clustered based on the interaction score values, using the clustermap function in Python’s seaborn library with default parameters. Source data are provided as a Source Data file.