Table 1 The sequence, assembled behavior, targeting and tailoring capability of different designed molecules.
Name | Molecular sequencea | Critical assembly concentration (CAC)b (μM) | Targeting receptor | Tailoring enzyme |
|---|---|---|---|---|
M1 | mPEG-GPAKLVFFGC(IR783)GRGD | >500 | αvβ3 | FAP-α |
M2 | mPEG-AGGKLVFFGC(IR783)GRGD | >500 | αvβ3 | – |
M3 | mPEG-GPAKLVFFGCGRGD | >303.7 | αvβ3 | FAP-α |
R-M1 | AKLVFFGC(IR783)GRGD | 37.2 | αvβ3 | – |
M4 | mPEG-GPAKLVFFGC(IR783)GDTG | >500 | – | FAP-α |
M5 | mPEG-AGGKLVFFGCGRGD | >332.7 | αvβ3 | – |
R-M3 | AKLVFFGCGRGD | 19.2 | αvβ3 | – |
