Table 1 Summary of tested data and discovered cis-quantitative trait loci.

From: Tissue-specific multi-omics analysis of atrial fibrillation

Results for all available transcriptomics and proteomics measurements

 

Tested

FDR < 0.05:

P < 1 × 10−5

 
 

SNPs

Pairs

Genes

Pairs

Genes

Loci

Pairs

Genes

Loci

N

eQTL

4,861,118

56,139,851

16,306

57,403

1058

1657

40,267

552

870

75

pQTL

2,323,504

4,508,654

1337

4081

91

139

2543

45

71

75

Results only for genes with both transcriptomics and proteomics measurements

eQTL

2,249,758

4,198,168

1243

4603

124

201

3218

64

109

75

pQTL

2,249,758

4,198,168

1243

3906

87

133

2406

42

66

75

ratioQTL

2,249,758

4,198,168

1243

563

16

23

575

18

27

66

  1. Discovered cis-QTLs in human heart right atrial appendage tissue for mRNA and protein measurements. Two-sided t-tests were evaluated and Benjamini-Hochberg procedure to calculate FDR per omic was applied to account for multiple comparisons. Listed are the results for significance thresholds FDR < 0.05 and nominal P-value < 1 × 10−5. Loci denote the number of independent loci derived by LD clumping. Source data are provided as a Source Data file.
  2. QTL quantitative trait loci, FDR false discovery rate, LD linkage disequilibrium, eQTL expression quantitative trait loci, pQTL protein quantitative trait loci, N sample size.
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