Table 2 Trans-QTL results.

From: Tissue-specific multi-omics analysis of atrial fibrillation

Variant

Gene

Trans-QTL

GWAS SNP

QTL SNP

Chr

Position

Symbol

Chr

QTL

β

T value

P-value

FDR

rs9675122

rs11658168

chr17

7,406,134

TNNT2a,d

chr1

Transcript

−0.517

−4.27

6.43 × 10−5

0.081

rs9481842

rs9481842

chr6

118,974,798

NKX2-5b

chr5

Transcript

−0.593

−4.27

6.54 × 10−5

0.081

rs34292822

rs11588763

chr1

154,813,584

CYB5R3

chr22

Protein

−0.786

−4.89

6.86 × 10−6

0.113

rs34292822

rs11588763

chr1

154,813,584

NDUFB3c

chr2

Protein

−0.916

−4.44

3.56 × 10−5

0.133

rs9675122

rs11658168

chr17

7,406,134

HIBADH

chr7

Protein

−0.512

−4.43

3.66 × 10−5

0.133

rs34292822

rs11588763

chr1

154,813,584

NDUFA9d

chr12

Protein

−0.752

−4.42

3.85 × 10−5

0.133

rs34292822

rs11588763

chr1

154,813,584

DLAT

chr11

Protein

−0.716

−4.40

4.05 × 10−5

0.133

  1. Significant trans-eQTLs and pQTLs for a FDR < 0.2 (Benjamini-Hochberg procedure to account for multiple comparisons per omic). Two-sided t-tests were performed on 23 transcripts with 74 samples and 152 proteins with 73 samples of human heart right atrial appendage tissue for 108 variants associated with atrial fibrillation from the GWAS catalog (or their proxy, if the GWAS SNP was not measured). Calculations were carried out using the SNP rs11658168 as a proxy for the GWAS SNP rs9675122 as well as rs11588763 instead of the GWAS SNP rs34292822.
  2. eQTL expression quantitative trait loci, pQTL expression quantitative trait loci, QTL quantitative trait loci, FDR false discovery rate, GWAS genome-wide association study, SNP single-nucleotide polymorphism, Chr Chromosome.
  3. aMutation known to affect cardiovascular phenotypes.
  4. bMutation known to affect arrhythmias.
  5. cDifferential expression functional impairment for cardiovascular phenotypes.
  6. dDifferential expression or functional impairment for arrhythmias; For details to disease links in literature see Supplementary Table 12. Source data are provided as a Source Data file.
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