Fig. 1: Background and concept design.

a Representative examples of axially chiral axially chiral N-heterobiaryls. b State of the art of CADA using pyridine as an electrophile. c State of the art of CADA using pyridine as a nucleophile. d AASI for the synthesis of axially chiral enamides. e Atroposelective cycloisomerization to axially chiral arylquinolizones.