Fig. 1: Fluorine thiol displacement reactions (FTDRs).
From: Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
a A model reaction between benzyl thiol and the α-fluoroacetamide containing amino acid building block 9. b A model macrocyclization carried out between unprotected model peptide 18 and a commercially available linker 1,4-benzenedimethanethiol based on FTDR (pH = 9.0–9.5). The α-fluoroacetamide containing amino acid XL is highlighted in blue.
