Fig. 3: FTDR-based coupling between an unprotected Axin peptide analogue and various dithiol linkers with i, iā+ā4 linkage.
From: Unprotected peptide macrocyclization and stapling via a fluorine-thiol displacement reaction
a Coupling with the unprotected analogue 34 that has both L-fluoroacetamide substrates and the analogue 41 that has both d-fluoroacetamide substrates, respectively. b Coupling with the unprotected analogue 48 that has l-fluoroacetamide and d-fluoroacetamide (NāāāC direction), and analogue 52 that has d-fluoroacetamide and l-fluoroacetamide (NāāāC direction), respectively. c The reported Axin peptide analogue 56 was prepared based on ring-closing metathesis. d Circular dichroism (CD) spectra of all peptide analogues. Coupling amino acids XL/XD/S5 were highlighted in blue.
