Fig. 2: Correlation analysis of HP 13C-MRI metabolic parameters, 1H-MRI-derived apparent diffusion coefficient (ADC), %GP4, tumour cell composition, and expression of MCT1, MCT4, LDHA, and LDHB. | Nature Communications

Fig. 2: Correlation analysis of HP 13C-MRI metabolic parameters, 1H-MRI-derived apparent diffusion coefficient (ADC), %GP4, tumour cell composition, and expression of MCT1, MCT4, LDHA, and LDHB.

From: Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer

Fig. 2: Correlation analysis of HP 13C-MRI metabolic parameters, 1H-MRI-derived apparent diffusion coefficient (ADC), %GP4, tumour cell composition, and expression of MCT1, MCT4, LDHA, and LDHB.

Heatmaps representing the correlations between HP 13C-MRI metabolic parameters and: (a) 1H-MRI-derived ADC and histopathology-derived %GP4; and (b) histopathology-derived tumour epithelial and stromal cell numbers and the ratio of tumour epithelial-to-stromal cells, and RNAscope-derived tumour epithelial LDHA and LDHB expression (average mRNA copies per cell), combined epithelial LDH (summed copy numbers of LDHA and LDHB), and IHC-derived percentages of tumour and stromal cells expressing MCT1 and MCT4, respectively. For each correlation pair, the values were extracted from single ROIs encompassing the whole tumours to allow for appropriate correlation of the continuous quantitative outputs derived from different imaging and biological techniques used. Spearman’s correlation analysis was used in both cases, with asterisks denoting statistically significant correlations and colour scales representing the range of individual rank correlation coefficients. Individual Spearman’s rank correlation coefficients, their 95% confidence intervals, and P values for each of the presented correlation pairs are listed in Supplementary Information.

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