Fig. 1: Overview of Mannich reaction.
From: Multicomponent double Mannich alkylamination involving C(sp2)–H and benzylic C(sp3)–H bonds
a Classical Mannich reaction involving activated C(sp3)−H bond. b Mannich reaction involving C(sp2)−H bond of electron-rich arenes. c This work of double Mannich alkylamination for both C(sp2)−H and unactivated benzylic C(sp3)−H bond.
