Fig. 1: Mitochondrial MATα1 level is selectively reduced in alcohol-associated liver disease. | Nature Communications

Fig. 1: Mitochondrial MATα1 level is selectively reduced in alcohol-associated liver disease.

From: Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease

Fig. 1: Mitochondrial MATα1 level is selectively reduced in alcohol-associated liver disease.

Western blots (a) and densitometry analyses (b) of total, cytosolic and mitochondrial MATα1 in human normal and AH livers (n = 5 normal and n = 6 AH independent patients. p = 0.027 for total and p = 0.0006 for mitochondrial MATα1). Western blots (c) and densitometry analyses (d) of total, cytosolic and mitochondrial MATα1 in pair-fed and ethanol-fed mouse livers (n = 5 pair-fed and n = 6 ethanol-fed independent animals. p = 0.049 for total and p = 0.0004 for mitochondrial MATα1). Western blots (e, f) and densitometry analyses (g) of total, cytosolic and mitochondrial MATα1 in AML-12 cells treated with ethanol (n = 3 independent experiments. p = 0.018 for total and p = 0.024 for mitochondrial MATα1). Data are presented as mean values ± SEM. *p < 0.05. Statistical significance was determined by using two-tailed, one-sample t-test. Source data are provided as a Source data file. Total lysate is shown in white, cytosolic fraction in blue and mitochondrial fraction in red. AH alcoholic hepatitis.

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