Fig. 7: ∆Np63 regulates a common set of enhancer-associated genes in tracheal basal cells, AT2 cells and LUAD.
From: ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer
a Venn diagram overlaying the genes associated with the top 2000 enhancers in AT2 and basal cells. b Schematic of dCas9-p300 and dCas9-ΔNp63 sgRNA experiment. c–e Relative expression levels of ETV5 (c), BCL9L (d) and KRT5 (e) in 293 T cells over-expressing the indicated constructs. Data were mean ± SD, n = 3, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, two-tailed Student’s t-test. f–h qRT-PCR of ChIP assays for p300, H3K27ac and ΔNp63 at the indicated sites. Data were mean ± SD, n = 3, * vs. shNT, P < 0.05, two-tailed Student’s t-test. Source data are provided as a Source Data file.
