Fig. 8: BCL9L mediates the oncogenic activities of ∆Np63 and is critical for maintenance of LUSC and LUAD.
From: ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer
a Quantification of colony formation efficiency in soft agar of H520 LUSC cells and H358 LUAD cells infected with the indicated shRNAs. Data were mean ± SD, n = 3, *P < 0.05, **P < 0.01, ****P < 0.0001, vs. respective shNT, two-tailed Student’s t-test. b Tumour volume quantification of xenograft tumours derived from the indicated cell lines. Boxplots represent the individual data points, median and whiskers (min to max method) are shown, n = 5, * vs. respective shNT, P < 0.05, two-tailed Student’s t-test. c Quantification of colony formation efficiency in soft agar of H520 LUSC cells and H358 LUAD cells transfected with the indicated constructs. Boxplots represent the individual data points, median and whiskers (min to max method) are shown, n = 3, *P < 0.05, **P < 0.01, vs. respective siNT/empty, two-tailed Student’s t-test. d Venn diagram overlaying genes associated with the top 2000 enhancers in AT2 cells and LUAD derived from KrasG12D/+ mice. e, f Kaplan–Meier curves of overall lung adenocarcinoma survival data based on the levels of BCL9L in the indicated cohorts. Source data are provided as a Source Data file.
