Fig. 3: GTN induces PMA via CGRP released from periorbital trigeminal terminals and, CLR/RAMP1 in Schwann cells. | Nature Communications

Fig. 3: GTN induces PMA via CGRP released from periorbital trigeminal terminals and, CLR/RAMP1 in Schwann cells.

From: Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice

Fig. 3: GTN induces PMA via CGRP released from periorbital trigeminal terminals and, CLR/RAMP1 in Schwann cells.The alternative text for this image may have been generated using AI.

a PMA and (b) paw mechanical allodynia induced by intraperitoneal (i.p.) GTN (10 mg/kg) or vehicle in Adv-Cre+/Ramp1fl/fl or Control mice post-treated (1.5 hs after GTN) with olcegepant (1 nmol) or vehicle. (c) PMA and (d) paw mechanical allodynia induced by GTN (10 mg/kg, i.p.) or vehicle in Plp1-CreERT+/Ramp1fl/fl or Control (treated with periorbital 4-OHT or vehicle) post-treated (1.5 hs after GTN) with olcegepant (1 nmol) or vehicle. Mean±SEM., n = 8 mice per group. ***P < 0.001 vs. Control-Veh/Veh; §§§P < 0.001 vs. Control-GTN/Veh. 2-way ANOVA, Bonferroni correction. Source data are provided as a Source Data file.

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